Expressions of OCT4, Notch1 and DLL4 and their clinical implications in epithelial ovarian cancer
10.3969/j.issn.1673-4254.2017.04.04
- VernacularTitle:上皮性卵巢癌中八聚体结合转录因子4、Notch1及DLL4的表达及其临床意义
- Author:
Lan YU
1
;
Yunjie JIAO
;
Lei ZHOU
;
Wenqing SONG
;
Shiwu WU
;
Danna WANG
Author Information
1. 蚌埠医学院第一附属医院病理科//蚌埠医学院病理学教研室//安徽省感染与免疫重点实验室
- Keywords:
epithelial ovarian cancer;
OCT4;
Notch1;
DLL4;
prognosis
- From:
Journal of Southern Medical University
2017;37(4):444-450
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlations among OCT4, Notch1 and DLL4 and their association with the clinicopathological features of patients with epithelial ovarian cancer (EOC). Methods A total of 207 specimens of EOC and 65 specimens of benign ovarian epithelial tumor tissues were examined for expressions of OCT4, Notch1 and DLL4 proteins using immunohistochemistry. Results The positivity rates of OCT4, Notch1 and DLL4 in EOC tissues were 60.0%, 61.8%and 60.9%, respectively, significantly higher than the rates in benign epithelial tumor tissues (9.2%, 6.2%, and 0, respectively; P<0.05). The expressions of OCT4, Notch1 and DLL4 in EOC were significantly correlated with tumor differentiation, FIGO stage, and lymph node metastasis (P<0.05). DLL4 was positively correlated with OCT4 and Notch1 expressions (r=0.758 and 0.704, respectively, P<0.001), and the latter two were also positively correlated (r=0.645, P<0.001). Overexpressions of OCT4, Notch1 and DLL4 were associated with a poor prognosis, and the survival rate was significantly lower in patients positive for OCT4, Notch1, and DLL4 than in the negative patients (P<0.05). FIGO stage and expressions of OCT4 and DLL4 were independent prognostic factors of EOC (P<0.05). Conclusion The expressions of OCT4, Notch1 and DLL4 are correlated with the differentiation, lymph node metastasis, clinical stage and prognosis of EOC. Combined detection of the 3 proteins has an important value in predicting the progression and prognosis of EOC.
