Embryo selection in IVF/ICSI cycles using time- lapse microscopy and the clinical outcomes
10.3969/j.issn.1673-4254.2015.12.19
- VernacularTitle:使用time-lapse筛选早期IVF/ICSI胚胎及其临床结局
- Author:
Minghao CHEN
1
;
Jun HUANG
;
Ying ZHONG
;
Song QUAN
Author Information
1. 南方医科大学南方医院妇产科生殖医学中心
- Keywords:
time-lapse microscopy;
traditional morphological method;
embryo selection;
clinical pregnancy rate;
implantation rate
- From:
Journal of Southern Medical University
2015;(12):1760-1764,1781
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical outcomes of embryos selected using time-lapse microscopy and traditional morphological method in IVF/ICSI cycles and evaluate the clinical value of time-lapse microscopy in early embryo monitoring and selection. Methods We retrospectively analyzed the clinical data of 139 IVF/ICSI cycles with embryo selection based on time-lapse monitoring (TLM group, n=68) and traditional morphological method (control group, n=71). The βHCG-positive rate, clinical pregnancy rate and embryo implantation rate were compared between the 2 groups. Subgroup analysis was performed in view of female patients' age and the fertilization type. Results TheβHCG-positive rate, clinical pregnancy rate and implantation rate were 66.2%, 61.8%and 47.1%in TLM group, significantly higher than those in the control group (47.9%, 43.7%and 30.3%, respectively;P<0.05). Compared with patients below 30 years of age, patients aged between 31 and 35 years benefited more from time-lapse monitoring with improved clinical outcomes. time-lapse monitoring significantly increased theβHCG-positive rate, clinical pregnancy rate and implantation rate for patients undergoing IVF cycles, but not for those undergoing ICSI or TESA cycles. Conclusion Compared with those selected using traditional morphological method, the embryos selected with time-lapse microscopy have better clinical outcomes, especially in older patients (31-35 years of age) and in IVF cycles.
