Temporal variation of serum interleukin-37 and its relation with C-reactive protein in patients with acute ST-segment elevation myocardial infarction
10.3969/j.issn.1673-4254.2015.12.17
- VernacularTitle:急性ST段抬高型心肌梗死患者血清白介素-37表达的时间变化及与C反应蛋白的关系
- Author:
Nqin HE
1
;
Shuxin SHEN
;
Yan WANG
;
Shengcun GUO
;
Junfen WANG
;
Jianping BIN
Author Information
1. 广州市南沙中心医院心内科
- Keywords:
acute ST-segment elevation myocardial infarction;
interleukin-37;
C-reactive protein;
inflammation
- From:
Journal of Southern Medical University
2015;(12):1751-1754
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the temporal changes of serum interleukin-37 (IL-37) concentration following acute ST-segment elevation myocardial infarction (ASTEMI) and the relationship between IL-37 and C-reactive protein (CRP) in patients with ASTEMI. Methods This analysis was conducted in a cohort of 20 patients with an established diagnosis of ASTEMI and 26 patients admitted for chest pain but with normal findings in coronary angiography (control) between June 2012 and December 2013. Venous blood was collected at days 1, 3, 5, and 7 after myocardial infarction for measurement of serum IL-37 and CRP levels using enzyme-linked immunosorbent assay (ELISA). Results Compared with the control group, the patients in ASTEMI group showed a significant acute elevation of IL-37 level on day 1 following myocardial infarction; IL-37 level reached the peak on day 3 and began to decrease on day 5, followed by a significant decrease on day 7. The time course of post-infarction CRP changes was consistent with that of IL-37 variations and showed a positive correlation the latter (r=0.63, P<0.05). Conclusion IL-37 may participate in the inflammatory responses in ASTEMI.
