Expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and the clinicopathological implications
10.3969/j.issn.1673-4254.2015.07.26
- VernacularTitle:SFRP4和DKK1在宫颈鳞癌中的表达及临床病理意义
- Author:
Xiufen LI
1
;
Anli HOU
;
Zhenhuan LI
;
Shuqin FANG
;
Yali ZHANG
;
Yawei XU
Author Information
1. 承德医学院附属医院妇科
- Keywords:
cervical squamous cell carcinoma;
DKK1;
SFRP4;
immunohistochemistry;
reverse transcriptase-polymerase chain reaction
- From:
Journal of Southern Medical University
2015;(7):1063-1067
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of SFRP4 and DKK1 in cervical squamous cell carcinoma and explore the clinicopathological implications. Methods Immunohistochemistry and reverse transcriptase-polymerase chain reaction (RT-PCR) were used to detect the expressions of SFRP4 and DKK1 in 66 cervical squamous cell carcinoma and 26 normal cervical specimens. Results SFRP4 expression was significantly higher (P<0.01) and DKK1 expression was significantly lower (P<0.05) in the carcinoma tissues than in normal cervical tissues. DKK1 was negatively correlated with SFRP4 in the carcinoma tissues (P<0.01), and their expressions were associated with the clinical stages, tumor differentiation, depth of invasion and lymph node metastasis of the tumors (P<0.05). Conclusion SFRP4 and DKK1, the upstream components of the Wnt pathway, play a key role in the tumorigenesis of cervical squamous cell carcinoma, and their expressions are associated with the clinicopathological features of the malignancy.
