Value of serum beta-human chorionic gonadotropin on day 9 and 11 after embryo transfer in predicting pregnancy outcomes
10.3969/j.issn.1673-4254.2015.07.23
- VernacularTitle:胚胎移植术后9和11d血清β-HCG值对妊娠结局的预测价值
- Author:
Cairong CHEN
1
;
Song QUAN
;
Qiuxiang WANG
;
Yanhong LI
;
Peichang QIU
;
Xiaoying ZHAO
;
Linrong ZHOU
;
Haiyan GUO
Author Information
1. 南方医科大学南方医院妇产科生殖医学中心
- Keywords:
serum beta-human chorionic gonadotropin;
embryo transfer;
pregnancy outcomes
- From:
Journal of Southern Medical University
2015;(7):1050-1054
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of serum beta-human chorionic gonadotropin (β-HCG) on days 9 (d9) and 11 (d11) after fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) in predicting the pregnancy outcomes. Methods A total of 227 fresh ET and FET cycles performed at the Center of Reproductive Medicine, Qingyuan People's Hospital between Dec, 2012 and Feb, 2014 were analyzed. The data of serumβ-HCG levels on d9 and d11 after fresh ET and FET cycles and the pregnancy outcomes were reviewed, and the ROC curve was constructed to determine the optimal cut-off level of serum β-HCG level for predicting pregnancy outcomes. Results According to pregnancy outcomes, the cycles were divided into non-pregnancy group (group A), biochemical pregnancy group (group B), and clinical pregnancy group (group C). Significant differences were found between the mean serumβ-HCG levels measured on d9 and d11 in all the 3 groups (P<0.01). The cycles in group C were further divided into 5 subgroups with single pregnancy (C1), twin pregnancy (C2), early abortion (C3), ectopic pregnancy (C4), or intrauterine pregnancy complicated with ectopic pregnancy group (C5), and all the 5 subgroups showed significant differences inβ-HCG measurements between d9 and d11 (P<0.01). On d9 after ET and FET, the optimal cut-off level of serumβ-HCG was 49.05 IU/L for predicting for clinical pregnancy, and was 105.15 IU/L for predicting twin pregnancy; the two corresponding cut-off levels of serum β-HCG on d11 was 51.2 IU/L and 241.75 IU/L, respectively. Conclusion The absolute serumβ-HCG level on d9 and d11 after fresh ET and FET allows an accurate diagnosis of pregnancy and helps in the prediction of the pregnancy outcomes.
