Effect of Radix euphorbiae pekinensis extract on bioavailability of paclitaxel after their oral co-administration
- VernacularTitle:京大戟对紫杉醇口服生物利用度的影响
- Author:
Minghua LI
1
;
Li PENG
;
Fuheng YANG
;
Sijia LIU
;
Shengqi WANG
Author Information
1. 顺德区龙江医院
- Keywords:
paclitaxel;
Radix euphorbiae pekinensis;
P-glycoprotein;
Ussing chamber;
permeability;
oral bioavailability
- From:
Journal of Southern Medical University
2015;(6):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Radix euphorbiae pekinensis extract on the permeability and bioavailability of paclitaxel co- administered orally. Methods Based on Ussing Chamber and in vivo experiment, the permeability and bioavailability of paclitaxel were evaluated after oral co-administration with radix euphorbiae pekinensis in rats. The contents of paclitaxel in the permeates and the blood samples were determined using HPLC and LC-MS/MS method, respectively. Results In Radix euphorbiae pekinensis co-administration group, the Papp of the mucosal-to-serosal (M-S) transport or serosal-to-mucosal transport (S-M) of paclitaxel in the jejunum or ileum segment differed significantly from those in verapamil co-administration group and blank control group (P<0.05), but the Papp of S-M transport in the colon showed no significant difference from that in the blank control group. In the blank group, the average absolute bioavailability (AB%) of orally administered paclitaxel was only 2.81%, compared to that of 7.63%in radix euphorbiae pekinensis group. The average AB%in verapamil group was about 1.5 times that of the blank group. Conclusion Co-administration of Radix euphorbiae pekinensis extract can increase the bioavailability of orally administered paclitaxel.
