Prophylactic antibiotics:a necessity in totally percutaneous thoracic endovascular aortic re-pair?
- VernacularTitle:预防性抗生素在导管室进行完全经皮穿刺主动脉覆膜支架植入术的应用
- Author:
XIENianjin
1
;
Songyuan LUO
;
Ling XUE
;
Wei LI
;
Mengnan GU
;
Yuan LIU
;
Wenhui HUANG
;
Pengcheng HE
;
Ruixin FAN
;
Jiyan CHEN
;
Jianfang LUO
Author Information
1. 广东省心血管研究所//广东省人民医院//广东省医学科学院心血管内科
- Keywords:
aortic dissection;
endovascular repair;
infection;
postimplantation syndrome;
prophylactic antibiotics
- From:
Journal of Southern Medical University
2015;(4):578-582
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the benefit of prophylactic antibiotics (PA) in totally percutaneous aortic endovascular repair (PEVAR) in the catheterization laboratory for reducing stent-graft infection and postimplantation syndrome (PIS). Methods The clinical data were analyzed of patients undergoing thoracic endovascular aortic repairs. The patients were divided into non-PA group and PA group according to the use of prophylactic antibiotics before PEVAR. The diagnosis of infection was made by two senior physicians with reference to Hospital Acquired Infection Diagnostic Criteria Assessment released by the Ministry of Health of China. Results The 95 enrolled patients included 35 with PA and 60 without PA group, who were comparable for baseline characteristics. Infection-related deaths occurred in 1 case in non-PA group and retrograde Stanford type A dissection and death occurred in 1 case in PA group (1.67%vs 2.85%, P=1.00). The PA and non-PA groups showed no significant difference in the incidence of postoperative infection (5%vs 2.86%, P=1.000), hospital stay (9.30±7.21 vs 10.06±5.69, P=0.094), infection-related mortality (1.67% vs 0%, P=1.00), or postoperative fever (70.90% vs 91.43%, P=0.20). The body temperature showed significant variations at different time points after procedure (F=19.831, P<0.001) irrelevant to the use of prophylactic antibiotics (F=0.978, P=0.326). Conclusion The current data do not support the benefit of PA in reducing postoperative infection and PIS in patients undergoing PEVAR, but the patients without PA may have worse clinical outcomes in the event of postoperative infections.