Changes of left ventricular function in cirrhotic patients and their correlation with the mod-el for end-stage liver disease score
- VernacularTitle:肝硬化患者左心功能变化与终末期肝病模型评分的相关性研究
- Author:
Xiaopeng LI
1
;
Shanshan YU
;
Lu LI
;
Donggang HAN
;
Shejiao DAI
;
Ya GAO
Author Information
1. 西安交通大学医学院第二附属医院超声研究室
- Keywords:
liver cirrhosis;
cardiac function,left;
echocardiography;
cirrhotic cardiomyopathy
- From:
Journal of Southern Medical University
2015;(4):557-561
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of left ventricular structure and function in patients with liver cirrhosis and their correlation with the model for end-stage liver disease (MELD) score. Methods A total of 89 cirrhotic patients admitted between June, 2012 and June, 2014 and 30 healthy control subjects were enrolled in the study. According to MELD score, the cirrhotic patients were divided into 3 groups with MELD scores≤9, between 10 and 19, and≥20. The parameters of the left ventricle in resting state were measured using Doppler echocardiography, including left ventricular end systolic diameter (LVESD), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left atrial diameter (LAD), ejection fraction (LVEF), cardiac output (CO), mitral flow velocity, and E wave deceleration time (DT), and evaluated their relationship with MELD score. Results Compared with the control subjects, the cirrhotic patients showed significantly increased LVESD, LVEDD, IVST, LAD, CO and DT but reduced VE/VA ratio (P<0.05 or 0.01). The values of LVESD, LVEDD, IVST, LAD and DT increased gradually with MELD scores (P<0.05 or 0.01). VE/VA ratio was higher in patients with MELD score of 10-19 than in those with MELD score≤9, and decreased significantly in those with MELD score≥20. Of the cirrhotic patients, 55%were found to have left atrial enlargement and 44%had a VE/VA ratio≤1;left atrial enlargement and a VE/VA ratio below 1 were more common in patients with a MELD score≥20 than in those with lower MELD scores. The LAD, LVEDD and DT were positively correlated with MELD scores (r=0.208, 0.319 and 0.197, respectively;P<0.05 or 0.01). Conclusion The patients with liver cirrhosis can have cardiac function deficiency manifested mainly by left ventricular diastolic dysfunction in positive correlation with the severity of liver disease.
