The correlation between platelet parameters and acute rejection after renal transplantation
10.3969/j.issn.1673-4254.2015.03.20
- VernacularTitle:血小板参数与肾移植术后急性排斥反应的关系
- Author:
Shaojie FU
1
;
Yongjie LIANG
;
Lixin YU
;
Min LUO
;
Yibin WANG
;
Chuanfu DU
;
Junsheng YE
;
Lulu XIAO
Author Information
1. 南方医科大学南方医院 器官移植科
- Keywords:
platelets;
renal transplantation;
acute graft rejection
- From:
Journal of Southern Medical University
2015;(3):413-416
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between acute graft rejection early after renal transplantation and the variations of platelet parameters. Methods We retrospectively analyzed the clinical data of 167 renal transplant recipients before and within 2 months after the surgery. Before and at 1-10 days, 15 days, 30 days, 45 days and 60 days after the transplantation, 5 platelet parameters, including platelet count (PLT), platelet hematocrit (PCT), mean platelet volume (MPV), platelet volume distribution width (PDW), and large platelet ratio (P-LCR), were detected in the 35 patients with acute graft rejection within two months (AR group) and in the other 132 recipients with good graft recovery (control group). Results The AR group and control group showed no significant difference in PLT, PCT, MPV, or P-LCR before the surgery, but the PDW was significantly higher in the AR group (t=2.18, P=0.035). These parameters were similar within 5 postoperative days between the two groups (P>0.05), but in postoperative days 6-15, the AR group showed significantly increased MPV, PDW and P-LCR compared with the control group (P<0.05). In postoperative days 6-9, MPV, PDW and P-LCR became stable in AR group but tended to decrease in the control group, showing obviously different patterns of variation between the two groups (P<0.05). Conclusions Preoperative PDW may have a positive correlation with acute graft rejection after renal transplantation. Monitoring the variations of MPV, PDW and P-LCR may help in the diagnosis of acute graft rejection early after renal transplantation.
