Changes in muscle spindle afferent discharge activities in rat soleus following hindlimb im-mobilization
10.3969/j.issn.1673-4254.2015.02.19
- VernacularTitle:后肢制动对肌梭传入放电活动的影响
- Author:
Xuehong ZHAO
1
;
Wenjing ZHANG
;
Xi ZHOU
;
Yan GAO
;
Xiaoli FAN
;
Guangbin LIU
Author Information
1. 湖北文理学院医学院机能学部
- Keywords:
muscle spindle;
intrafusal fibre;
hindlimb unloading;
immobilization;
discharge
- From:
Journal of Southern Medical University
2015;(2):252-255
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes in the afferent discharge activities of the sensory nerve endings in muscle spindles of rats with hindlimb immobilization. Methods Plaster cast was used immobilize the hindllimbs of rats. Using air-gap technique, the spontaneous discharge of the muscle spindles and its responses to perfusion with succinylcholine (0.05 mg/ml) and suspension in an extended position were observed in isolated muscle spindles from rats with hindlimb immobilization for 3, 7, and 14 days. Results The muscle spindles of rat soleus showed a sharp decrease in spontaneous discharge frequency (P<0.01) and response to succinylcholine perfusion after 3 days of hindlimb immobilization (P<0.05). Significant changes of the firing rate in an extended position was observed in rats after a 14-day immobilization (P<0.01). The duration of individual spikes was significantly prolonged following hindlimb immobilization (P<0.01). Conclusion Muscle spindle discharges decrease significantly in rats following hindlimb immobilization, which might be related to reduced contractile properties of the muscle spindle.
