Diagnostic value of urine HBV DNA for hepatitis B virus-associated glomerulonephritis
- VernacularTitle:尿HBV DNA在乙型肝炎病毒相关性肾炎诊断中的价值
- Author:
Lifen WANG
1
;
Zhiming YE
;
Lixia XU
;
Bin ZHANG
;
Huaban LIANG
;
Zhonglin FENG
;
Shuangxin LIU
;
Wei SHI
Author Information
1. 广东省医学科学院/广东省人民医院肾内科
- Keywords:
urine HBV DNA;
hepatitis B virus;
glomerulonephritis;
HBV-associated glomerulonephritis
- From:
Journal of Southern Medical University
2014;(11):1705-1707
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential value of urine hepatitis Bvirus (HBV) DNA as a new noninvasive diagnostic indicator for HBV-associated glomerulonephritis (HBV-GN). Methods A total of 152 patients including 66 with HBV-GN, 66 with non-HBV-GN, and 20 with chronic hepatitis B(CHB) without renal disease were examined for serum and urine HBV DNA levels using polymerase chain reaction (PCR) and for 5 serum HBV markers using enzyme-linked immunosorbent assays. Results Twenty-two patients (33%) in the HBV-GN group, but none in the other two groups, were found positive for urine HBV DNA. In the diagnosis of HBV-GN, urine HBV DNA had a high specificity (0.98), a good positive predictive value (PPV, 0.96), and a modest negative predictive value (NPV, 0.60). Urine HBV DNA, alone or in combination with serum HBeAg, was superior in the diagnosis of HBV-GN to the combination of urine HBV DNA with serum HBV DNA, hepatitis Bsurface antigen and the hepatitis Be antigen. Conclusion Urine HBV DNA may be one of the new noninvasive diagnostic criterion for HBV-GN.
