Comparison of Umbilical Venous Erythropoietin Concentration Between Non-meconium Stained Neonates and Meconium Stained Neonates of Term Pregnancy.
- Author:
So Hyun LEE
1
;
Bo Hyun PARK
;
Mi Hye PARK
;
So Yeon WOO
;
Hye Sook PARK
;
Eun Ae PARK
;
Eun Hee HA
;
Young Ju KIM
;
Sun Hee CHUN
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine Ewha Womans' University, Seoul, Korea. kkyj@ewha.ac.kr
- Publication Type:Original Article
- Keywords:
Erythropoietin;
Nucleated erythrocyte;
Meconium stained neonates;
Intrauterine hypoxia;
Interleukin-6
- MeSH:
Amniotic Fluid;
Anoxia;
Enzyme-Linked Immunosorbent Assay;
Erythroblasts;
Erythropoietin*;
Female;
Fetal Hypoxia;
Gestational Age;
Hematocrit;
Humans;
Infant, Newborn*;
Interleukin-6;
Leukocytes;
Linear Models;
Meconium*;
Pregnancy*
- From:Korean Journal of Perinatology
2006;17(3):310-316
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine whether meconium staining can be the indicator of intrauterine hypoxia by comparing umbilical venous erythropoietin (EPO) concentration and the number of nucleated erythrocytes (NRBC), as a marker of intrauterine hypoxia, between non meconium-stained neonates and meconium-stained neonates of term pregnancy. And to determine correlation between the number of NRBC, EPO levels and interleukin-6 (IL-6), as another mediator of intrauterine hypoxia. METHODS: In 240 neonates with gestational age ranged from 37 to 41 weeks, including 231 cases of nonmeconium-stained neonates and 9 cases of meconium-stained neonates, we performed the measurement of EPO levels by RIA, the number of NRBC per 100 white blood cells (WBC) by blood smear and IL-6 by ELISA in umbilical venous blood at delivery. Statistical analysis was performed by chi-square test, Wilcoxon rank sum test, linear regression analysis using SPSS 11.0 version statistical package. RESULTS: Amniotic fluids of meconium-stained neonates had significantly greater EPO concentrations compared with that of nonmeconium-stained controls (41.3+/-13.0 vs 26.5+/-18.9 mIU/mL, p=0.001). But there were no statistical difference in the number of NRBC, IL-6 levels and hematocrit of umbilical venous blood. The EPO levels in umbilical venous blood was correlated with the number of nucleated erythrocytes (r2=7.7%, p<0.001), and IL-6 in umbilical venous blood was correlated with the number of NRBC. (r2=11.5%, p<0.001). CONCLUSION: These results suggest that meconium-stained amniotic fluid can be associated with fetal hypoxia. And the production of fetal NRBC is thought to be stimulated by EPO and IL-6, but it requires further study of other (yet to be determined) hypoxia-derived mediators.
