Resveratrol enhances radiosensitivity of human hypopharyngeal carcinoma cell line in nude mice
10.3969/j.issn.1673-4254.2014.11.18
- VernacularTitle:白藜芦醇对人下咽鳞状细胞癌裸鼠移植瘤的放射增敏作用
- Author:
Fang QUAN
1
;
Qian ZHAO
;
Yuan SHAO
;
Honghui LI
;
Ruimin ZHAO
Author Information
1. 西安交通大学医学院第一附属医院耳鼻咽喉头颈外科
- Keywords:
hypopharyngeal cancer;
resveratrol;
radiosensitization
- From:
Journal of Southern Medical University
2014;(11):1646-1649
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the radiosensitizing effect of resveratrol on human hypo pharyngeal squamous cell carcinoma (FaDu) cells in nude mice. Methods Forty-three nude mice bearing FaDu cell xenografts were randomized into control group, radiotherapy (12 Gy) group, resveratrol treatment (50 mg/kg) group, and radiotherapy plus resveratrol treatment group. After corresponding treatments, the tumor volume in the mice was measured every 3 days, and the microvessel density (MVD) in the tumor was evaluated with CD31 immunofluorescence histochemical staining. Results The tumor volume and weight were the smallest in mice receiving radiotherapy plus resveratrol treatment (P<0.05) but comparable between those having resveratrol treatment alone and the control mice. Radiotherapy plus resveratrol treatment resulted in a tumor inhibition rate of 76.64% and a significantly decreased MVD in the tumor compared with the other 3 groups. Conclusion Resveratrol can produce a radiosensitizing effect on human hypopharyngeal carcinoma in nude mice.
