Pathological study of cerebral amyloid angiopathy in rat models of Alzheimer's disease
10.3969/j.issn.1673-4254.2014.07.11
- VernacularTitle:阿尔茨海默氏病大鼠淀粉样变性脑血管病的病理学变化
- Author:
Tianming LÜ
1
;
Yanshan LIANG
;
Cuili SHI
;
Xiaoyu HUANG
;
Zhiyong PAN
;
Rong LING
;
Wenling ZHANG
;
Mengxi HAO
;
Qiuyao GUO
;
Yu ZENG
;
Jia YIN
Author Information
1. 南方医科大学第三附属医院神经内科
- Keywords:
cerebral amyloid angiopathy;
Alzheimer's disease;
β-amyloid;
rats
- From:
Journal of Southern Medical University
2014;(7):969-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To examine cerebral pathologies in cerebral amyloid angiopathy in a rat model of Alzheimer's disease. Methods Rat models of Alzheimer's disease was established by stereotactic Aβ1-42 fiber injection in the bilateral hippocampus. The cognitive function of the rats was evaluated with water maze test. HE staining, Congo red staining and double-labeling indirect immunofluorescence were used to examine the dynamic distribution of Aβ fiber deposit in the brain. Results The model rats showed significant differences from the control rats in the escape latency and the times of crossing platform in waster maze test. HE staining revealed a decreased number and degeneration of the granular cells with increased glial cells in the model rats. Congo Red staining showed that the Aβ fiber was deposited gradually in the small vessels in the brain parenchyma to cause thickening, stenosis or occlusion of the small vessels. Immunofluorescence staining detected Aβ fiber migration from the parenchyma to the walls of the small arteries in the rat models. Conclusion Cerebral amyloid angiopathy is a major pathological feature in Alzheimer's disease.
