Inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses
10.3969/j.issn.1673-4254.2014.07.09
- VernacularTitle:3-三氟甲基苯甲酰胺类衍生物对H5N1流感病毒进入靶细胞的抑制活性
- Author:
Zhibo ZHU
1
;
Yun CAI
;
Jie YANG
;
Xianglian LI
;
Runming LI
;
Shuwen LIU
Author Information
1. 南方医科大学药学院
- Keywords:
H5N1 avian influenza virus;
influenze virus entry inhibitor;
hemagglutinin;
benzamide
- From:
Journal of Southern Medical University
2014;(7):961-964
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the inhibitory activities of 3-trifluoromethyl benzamide derivatives against the entry of H5N1 influenza viruses. Methods The lead compound was structurally modified to obtain 3 compounds with inhibitory activities against H5N1 influenza viruses. Specs compound librany was screened and 4 compounds were identified to have such inhibitory activities. The inhibitory activities of these compounds were tested at a celluar level against H5N1 influenza viruses. Results and Conclusion The compounds 1a, 1b, 1e and 1f showed signifcant inhibitory activities against the entry of A/AnHui/1/2005 pseudovirus into the target cells with an IC50 value of 4.7±0.3μmol/L.
