Extraosseous Ewing's Sarcoma Presented as a Rectal Subepithelial Tumor: Radiological and Pathological Features.
10.13104/imri.2017.21.1.51
- Author:
Heejin BAE
1
;
Taek CHUNG
;
Mi Suk PARK
;
Myeong Jin KIM
;
Joon Seok LIM
;
Honsoul KIM
Author Information
1. Department of Radiology, Yonsei University College of Medicine, Seoul, Korea. pine0205@yuhs.ac
- Publication Type:Case Report
- Keywords:
Ewing's Sarcoma;
Extraosseous Ewing's Sarcoma;
Rectal submucosal tumor;
Rectal MRI
- MeSH:
Aged;
Diagnosis;
Female;
Fluorescence;
Humans;
Immunohistochemistry;
In Situ Hybridization;
Magnetic Resonance Imaging;
Rectum;
Sarcoma, Ewing*
- From:Investigative Magnetic Resonance Imaging
2017;21(1):51-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Extraosseous Ewing's sarcoma (EOE) of the rectum is extremely rare: only three cases have been reported in the literature and none of these reports described their imaging findings in detail. Herein, we describe the tumor imaging and pathological features in detail. MATERIALS AND METHODS: We report a case of rectal EOE in a 72-year-old female who received local excision and was provisionally diagnosed with a rectal submucosal spindle cell tumor. We used immunohistochemistry, histopathology, and fluorescence in situ hybridization to characterize the tumor and provide a definitive diagnosis of EOE. RESULTS: MRI revealed a well-demarcated submucosal tumor with heterogeneous enhancement and hemorrhagic foci in rectum. EOE was diagnosed by positive staining of tumor cells for CD99 and Fli-1 by immunohistochemistry and the presence of the EWSR1 gene translocation by fluorescence in situ hybridization. Although the patient underwent radiation treatment and surgery, the tumor recurred after 4 months as revealed by computed tomography and magnetic resonance imaging. CONCLUSION: Rectal EOE may present as a rectal submucosal tumor. The understanding of imaging and histological characteristics of this tumor are critical for accurate diagnosis and appropriate aggressive treatment.
