Outcomes of percutaneous coronary intervention for intermediate coronary artery disease guided by intravascular ultrasound or fractional flow reserve
10.3969/j.issn.1673-4254.2014.05.23
- VernacularTitle:血管内超声或血流储备分数指导冠状动脉临界病变介入治疗的临床效果
- Author:
Huihua ZUO
1
;
Qiang LIU
;
Zhiling ZHANG
;
Lili WANG
;
Jianxin WENG
;
Yi WEI
;
Xinlin LUO
;
Qiying CHEN
;
Qian CAO
Author Information
1. 深圳市孙逸仙心血管医院心内科
- Keywords:
intermediate coronary lesion;
fractional flow reserve;
intravascular ultrasound;
percutaneous coronary intervention
- From:
Journal of Southern Medical University
2014;(5):704-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the long-term clinical outcomes of fractional flow reserve (FFR)-guided versus intravascular ultrasound (IVUS)-guided percutaneous coronary intervention (PCI) for intermediate coronary lesions. Methods A total of 226 patients with 293 intermediate coronary artery lesions (stenosis of 40%-70%) confirmed by coronary angiography were randomized into 3 groups to undergo PCI for a minimal lumen cross sectional area (MLA)<4 mm2 (IVUS group, 98 lesions) or for a FFR<0.80 (FFR group, 101 lesions), or to receive standard medical treatment (medication group, 94 lesions). The primary outcome was major adverse cardiac events including death, myocardial infarction, and ischemia- driven target vessel revascularization at 1 year after the index procedure. Results The baseline percent diameter stenosis and lesion length were similar between the 3 groups, but more patients in IVUS group than in FFR group received PCI (P<0.001). No significant difference was found in the incidence of major adverse cardiac events between the 3 groups (P=0.182). Conclusions Both FFR-and IVUS-guided PCI strategy for intermediate coronary artery disease are associated with favorable outcomes, but IVUS-guided PCI based on the single index of MLA can increase the rate of revascularization therapy.
