Correlation between TMEM39A gene polymorphism and systemic lupus erythematosus in Chinese Han patients
10.3969/j.issn.1673-4254.2014.04.25
- VernacularTitle:中国汉族TMEM39A基因单核苷酸多态性与系统性红斑狼疮的相关性
- Author:
Jun ZHANG
1
;
Yaqiong MA
;
Minzi QIU
;
Lei YANG
;
Yang BU
;
Xun TANG
Author Information
1. 南方医科大学珠江医院肾内科
- Keywords:
transmembrane protein 39A;
polymorphism;
systemic lupus erythematosus
- From:
Journal of Southern Medical University
2014;(4):556-559
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between single nucleotide polymorphisms (SNPs) of the transmembrane protein 39A (TMEM39A) at the loci 1880G/A, 2442T/G, and 2456A/T and systemic lupus erythematosus (SLE) in Chinese Han patients. Methods TMEM39A gene polymorphisms at 3 loci (1880G/A, 2442T/G, 2456 A/T) were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 110 Chinese Han patients with SLE and 80 normal control subjects, and the allele and genotype frequencies were compared by Chi-square test between the two groups. Results Both the genotype frequencies (AA, GA and GG) and allele frequencies (A and G) at 1880G/A differed significantly between SLE cases and the normal controls (P=0.002 and P=0.044, respectively). The two groups also showed significant differences in the genotype frequencies (GG, TG and TT) (P=0.001) and allele frequencies (G and T) (P=0.041) at 2442T/G. No significant differences were found in the genotype frequencies (TT, AT and AA) or allele frequencies (T and A) at 2456A/T between the two groups (P>0.05). The allele and genotype frequencies of the 3 SNPs showed no significant differences between lupus nephritis (LN) patients and non-LN patients. Conclusion The TMEM39A polymorphisms at 1880G/A and 2442T/G, but not at 2456 A/T gene, may be associated with the susceptibility to SLE in Chinese Han population. The genotype or allele frequencies of the 3 SNPs have no effect on the incidence of lupus nephritis.
