Value of dual-phase 18F-FDG PET/CT in preoperative staging of bladder cancer
10.3969/j.issn.1673-4254.2014.04.13
- VernacularTitle:18F-FDG PET/CT双时相显像在膀胱癌术前分期中的临床价值
- Author:
Hongsheng LI
1
;
Hubing WU
;
Qiaoyu WANG
;
Yanjiang HAN
;
Quanshi WANG
Author Information
1. 南方医科大学南方医院PET中心
- Keywords:
bladder cancer;
staging;
tomography;
emission-computed,deoxyglucose
- From:
Journal of Southern Medical University
2014;(4):500-503
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical value of dual-phase 18F-FDG PET/CT with oral diuretics in preoperative staging of bladder cancer. Methods The imaging data were analyzed of 73 patients with bladder cancer undergoing preoperative dual-phase 18F-FDG PET/CT with oral diuretic between May, 2003 and May, 2012. All the patients underwent whole-body PET/CT scan 60 min after intravenous injection of 270-350 MBq of 18F-FDG. Additional delayed pelvic PET/CT images were acquired after forced diuresis using oral furosemide (40 mg). All the patients underwent subsequent radical cystectomy, and 18F-FDG PET/CT findings were compared with the histopathologic results to evaluate the value of dual-phase 18F-FDG PET/CT in preoperative staging. Results The concordance rate of dual-phase FDG PET/CT-based bladder cancer staging with the histopathologic results was 63.0%in the 73 patients, and was 100%(7/7) for pT4 bladder cancers. With dual-phase FDG PET/CT, the detection rate was 75.0%(6/8) for lymph node metastases, 100%(4/4) for distant metastases, and 100%(4/4) for other concurrent primary malignancies. Conclusion Though with limited accuracy in T-staging of pTa, pT1, pT2, and pT3 bladder cancer, dual-phase FDG PET/CT has important clinical value in staging of pT4 bladder cancer and in N-staging, M-staging and detection of other concurrent primary malignancies.
