Effect of casein osphopeptide-amorphous calcium phosphate solution in preventing enamel demineralization

VernacularTitle:酪蛋白磷酸肽-非结晶型磷酸钙溶液预防牙釉质脱矿的实验研究
Author: Baojun LONG ¹ ; Ke CHEN ; Dongjie ZHANG ; Yunpeng LI
Author Information

1. 广州市妇女儿童医疗中心口腔科
Keywords: casein osphopeptide-amorphous calcium phosphate; demineralization; enamel; fluoride; scanning electron micros-copy
From: Journal of Southern Medical University 2014;(3):430-433
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effects of casein osphopeptide-amorphous calcium phosphate (CPP-ACP) in preventing enamel demineralization. Methods Enamel blocks were prepared from premolars extracted from orthodontic patients. The specimens were treated for 30 min daily for 7 days with one of the following agents:deionized water (negative control), CPP-ACP paste, and NaF solutions (positive controls) (0.2% and 2%). After the treatments, the specimens were immersed in a demineralizing solution (pH 4.5) for 7 days. The morphology and depth of the lesion were observed using scanning electron microscopy, and the content of Ca, P, Mg in the demineralized enamel was measured by electron probe micro-analyzer. Results The demineralization rates in all the treatment groups were significantly smaller than those in the control group after 7 days of demineralization. Conclusion The application of CPP-ACP to the enamel surfaces can inhibit enamel demineralization with an equivalent effect to 0.2%NaF.