Factors for predicting outcomes of liver transplantation and liver resection for hepatocellular carcinoma meeting Milan criteria
10.3969/j.issn.1673-4254.2014.03.24
- VernacularTitle:符合Milan标准肝细胞癌患者行肝移植和肝切除术预后分析
- Author:
Junhai HUANG
1
;
Jie ZHOU
Author Information
1. 南方医科大学南方医院肝胆外科
- Keywords:
Milan criteria;
hepatocellular carcinoma;
liver transplantation;
liver resection;
neoplasm recurrence;
prognosis
- From:
Journal of Southern Medical University
2014;(3):406-409
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors affecting neoplasm recurrence and metastasis following liver transplantation (LT) and liver resection (LR) in patients with hepatocellular carcinoma (HCC) meeting Milan criteria. Methods We retrospectively analyzed the clinical data of 88 patients with HCC meeting Milan criteria undergoing LT or LR in Nanfang Hospital between January, 2006 and December, 2011 and compared the survival rate and recurrence-free survival rate between the two groups. Univariate analysis of 12 variables during peri-operative period was carried out to screen the risk factors affecting neoplasm recurrence and metastasis. Results The LT group and HR group had similar 1-, 3-, and 5-year-survival rates (P>0.05), but the LT group showed significantly higher 1-, 3-, and 5-year recurrence-free survival rates (P<0.05). The recurrence rate was much lower in LT group than in LR group (P<0.05). Multivariate analysis identified gender, tumor size, degree of pathological differentiation, and microvascular tumor embolism as independent risk factors affecting the recurrence-free survival rate. Conclusions Patients with HCC meeting Milan criteria undergoing LT have longer long-term recurrence-free survival. A male patient with a greater tumor size, microvascular tumor embolism, and poorly differentiated carcinoma is more likely to develop neoplasm recurrence and metastasis following the surgery.
