Effect of donor and recipient anti-MICA antibodies on early renal graft function following transplantation
10.3969/j.issn.1673-4254.2014.03.19
- VernacularTitle:肾移植术后供受者MICA抗体对早期移植肾功能的影响
- Author:
Shaojie FU
1
;
Rumin LIU
;
Min LUO
;
Chuanfu DU
;
Yibin WANG
;
Jian XU
;
Lulu XIAO
;
Lixin YU
Author Information
1. 南方医科大学南方医院器官移植科
- Keywords:
renal transplantation;
major histocompatibility complex class I-related chain A;
graft function;
acute rejection
- From:
Journal of Southern Medical University
2014;(3):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of donor and recipient anti-major histocompatibility complex class I-related chain A (MICA) antibodies on early renal graft function in renal transplant recipients. Methods Using Luminex200 liquid chip technology, we detected anti-MICA antibodies in 26 deceased donors paired with 43 recipients. We divided the 43 pairs into 4 groups according to different donor and recipient anti-MICA antibody positivity statuses and compared the incidence of acute rejection (AR), serum creatinine at 1 week after transplantation, and renal function recovery time between the groups to assess the effect of donor and recipient anti-MICA antibodies on early graft function. Results Five of the 26 donors were positive for anti-MICA antibodies (19.2%), with the most common antibody being anti-MICA*019 (40%); 11 of the 43 recipients were positive for anti-MICA antibodies (25.6%), among which anti-MICA*018 was most frequently found (14.6%). AR did not occur in the only anti-MICA antibody-positive recipient receiving an anti-MICA antibody-positive donor graft;AR occurred in 2 (33.3%) of the 6 anti-MICA antibody-negative recipients receiving anti-MICA antibody-positive donor graft, in 4 (40%) out of the 10 anti-MICA antibody-positive recipients receiving anti-MICA antibody-negative donor graft, and in 10 (38.4%) of the 26 anti-MICA antibody-negative recipients receiving anti-MICA antibodies-negative donor graft. The incidences of AR were not significantly different between the groups (P>0.05), nor were serum creatinie levels or renal function recovery time at one week after surgery(P>0.05). Conclusion Donor or recipient anti-MICA antibody positivity does not seem to significantly affect the incidence of AR or renal function recovery early after transplantation to justify the necessity of monitoring donor anti-MICA antibodies. But still, large-sample studies are needed to further investigate the potential impact of donor and recipient anti-MICA antibodies on the outcomes of renal transplantation.
