Correlation between adipocytokines levels and metabolic syndrome in type 2 diabetes mellitus
- VernacularTitle:2型糖尿病患者脂肪细胞因子与代谢综合征的关系
- Author:
Ting YAN
1
;
Lingling LI
;
Huaiming WANG
;
Jiao WANG
;
Dehong CAI
Author Information
1. 南方医科大学珠江医院内分泌科
- Keywords:
metabolic syndrome;
adipocytokine;
visceral adipose tissue-derived serine protease inhibitor;
adiponectin;
interleukin-6
- From:
Journal of Southern Medical University
2014;(2):275-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between adipocytokines levels and metabolic syndrome (MS) in patients with newly diagnosed type 2 diabetes mellitus (T2DM). Methods Sixty-eight patients with newly diagnosed T2DM, including 51 cases with MS and 17 without MS, were examined for blood pressure (BP), fasting blood glucose (FBG), fasting insulin (FINS), insulin resistance index (IRI), waist to hip ratio (W/H), body mass index (BMI), and serum dipocytokine levels (IL-6, vaspin, and adiponectin). Results The diabeitc patients with MS had higher BMI, HbA1c, FBG, FINS, IRI, TG, TC, and SBP than those without MS. Serum IL-6 level was higher but adiponectin level was lower in patients with MS than in those without MS. There was no significant difference in vispin level between the two groups. Adiponectin level was positively correlated with TG (r=-0.30, P=0.02) and inversely with BMI (r=-0.47, P=0.39) and HOMA-IR (r=-0.30, P=0.03); vispin level was positively correlated with HOMA-IR (r=0.347, P=0.02) and inversely with HDL-L (r=-0.45, P=0.01);IL-6 level was positively correlated with LDL-L (r=0.18, P=0.25) and inversely with HDL-L (r=-0.45, P=0.01). Conclusion Adiponectin and IL-6 levels are closely related to MS, but the relationship between vispin and MS needs further invesitgation.