Effects of moxibustion at Shenque (CV8) on gastrointestinal function in rats undergoing gas-tric perforation repair
- VernacularTitle:温灸神阙穴对胃穿孔修补术后大鼠胃肠功能恢复的影响
- Author:
Quan ZHENG
1
;
Huaying LI
;
Xiaomin WEN
;
Kuncai ZHANG
Author Information
1. 南方医科大学中西医结合医院普通外科
- Keywords:
moxibustion;
Shenque(CV8);
gastric perforation repair;
gastrointestinal function
- From:
Journal of Southern Medical University
2014;(1):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effects of moxibustion at Shenque (CV8) in promoting gastrointestinal function recovery in rats following gastric perforation repair and explore the underlying mechanism. Methods Thirty male SD rats with glacial acetic acid-induced gastric perforation underwent surgical repair of the perforation. The rats were then randomized 8 days later into model group (n=10), domperidone group (n=10), and moxibustion group(n=10) and treated with physiologic saline, domperidone suspension, and moxibustion at Shenque (CV8), respectively. Gastric antral myoelectric activities of the rats were observed and peripheral blood levels of TNF-α, IL-6, and T lymphocyte subpopulation were determined. Results Gastric antral myoelectric activities in rats receiving moxibustion were stronger than those in the model group (P<0.05) but comparable with those in domperidone group (P>0.05). TNF-αand IL-6 level were decreased significantly and T lymphocyte subpopulations increased significantly in moxibustion group compared with those in the model and domperidone groups (P<0.05). Conclusion Moxibustion at Shenque (CV8) can promote the recovery of gastrointestinal functions in rats undergoing gastric perforation repair possibly by enhancing gastrointestinal electric activity, suppressing inflammation, and improving the cellular immune function, and can therefore serve as a simple and effective adjuvant therapy during the perioperative period.