Relations of fetuin- A with estimated glomerular filtration rate and carotid artery calcification in patients with chronic kidney disease
- VernacularTitle:胎球蛋白A与慢性肾脏病患者肾小球过滤及颈动脉钙化的关系
- Author:
Junlin ZHAN
1
;
Jianbo LIANG
;
Zebin WANG
Author Information
1. 广州医科大学附属第二医院儿科
- Keywords:
chronic kidney disease;
fetuin-A;
carotid artery;
calcification;
glomerular filtration rate
- From:
Journal of Southern Medical University
2013;(11):1689-1691
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of fetuin-A with residual renal function and carotid artery calcification in patients with chronic kidney disease (CKD). Methods Blood examples were collected form 60 CKD patients in stages CKD3 to CKD5 (20 patients per stage) for measurement of serum fetuin-A, albumin, calcium, phosphorus and parathyroid hormone, cholesterol, triglycercide, low-density lipoprotein, and high-density lipoprotein. MDRD equation was used to calculate the estimated glomerular filtration rate (eGFR), and ELISA was used to detect serum fetuin-A. Color Doppler ultrasound was performed to measure carotid intima-media thickness (CIMT). Results As the eGFR decreased, serum fetuin-A significantly decreased in CKD5 stage compared with that in CKD4 stage (P<0.05);compared with that in CKD3 stage, serum fetuin-A level was significantly lowered in CKD4 stage (P<0.05). Linear regression analysis suggested a significant positive correlation between fetuin-A and eGFR. The rate of carotid artery calcification was the highest in CKD5 stage. Rank correlation analysis showed a negative correlation between fetuin-A and cIMT, and logistic regression analysis identified decreased serum Fetuin-A as a risk factor of carotid artery calcification. Conclusion Serum fetuin-A decreases following the decrease in eGFR, and decreased serum Fetuin-A level is a risk factor of carotid artery calcification in CKD patients.
