Value of serum cystatin C level in assessing renal damage in preeclamptic patients
10.3969/j.issn.1673-4254.2013.09.28
- VernacularTitle:血清胱抑素C在评估重度子痫前期肾功能损害中的价值
- Author:
Shipeng GONG
1
;
Yeping CAI
;
Guidong SU
Author Information
1. 南方医科大学南方医院妇产科
- Keywords:
serum cystatin C;
severe preeclampsia;
renal function
- From:
Journal of Southern Medical University
2013;(9):1386-1389
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the significance of the serum cystatin C (Cys-C) in assessing renal dysfunction in preeclamptic women. Methods Ninety-six women with normal pregnancies and 48 with severe preeclampsia were examined for 24-hour creatinine clearance (CrCl), serum creatinine (Scr), Cys-C, uric acid (UA) and beta microglobulin (MG) concentrations during the second and third trimesters and postpartum in severe preeclamptic patients. These indexes were analyzed to estimate the glomerular filtration rate. Results The concentrations of Scr, UA and MG were significantly higher in the third trimester than in the second trimester in women with normal pregnancies, where serum Cys-C levels showed no significant variations. Severe preeclamptic patients exhibited significantly higher serum Cys-C levels in the third than in the second trimester. Correlation analyses demonstrated significant negative correlations between Cys-C and 24-hour CrCl in the second and third trimesters in all the 144 pregnant women and in the postpartum period in severe preeclamptic patients. Conclusion Serum Cys-C can serve as a good indicator for assessing renal function in severe preeclamptic women from antepartum to postpartum periods.
