Changes of lipoperoxide and nitric oxide levels in the sera of patients with coronary heart diseases

VernacularTitle:冠心病患者血清脂氢过氧化物和NO含量的变化
Author: Min-Zhen HUANG ¹ ; Mei ZHOU ; Yuan CHEN ; Jian ZHANG
Author Information

1. Nanfang Hospital
From: Journal of Southern Medical University 2001;21(4):301-302
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the changes in serum lipoperoxide (LOOH) and nitric oxide (NO) levels and the pathogenesis of coronary heart diseases (CHD). Methods The concentrations of LOOH in the sera of 33 healthy subjects and 33 patients with CHD were determined by ferrous oxidation in xylenol orange (FOX) assay, while those of NO by enzymatic one-step assay with nitrate reductase. Results The average serum concentration of LOOH in the patients was (7.64±3.26) μmol/L, much higher than that of healthy subjects [(5.78±3.21) μmol/L, P<0.05]. The NO level was (42.5±18.9) μmol/L in the patients and (51.4±17.8) μmol/L in the healthy subjects, showing significant difference between the 2 groups (P<0.05). Conclusion The increased LOOH and decreased NO levels in the serum might be involved in the pathogenesis of arteriosclerotic heart diseases.