Early use of high-potency antibiotics within short courses: a prospective clinical study

VernacularTitle:大面积深度烧伤后广谱高效抗生素早期短程使用的临床疗效
Author: Xin-Zhou RONG ¹ ; Wen-Zhen ZHANG ; Jia-Liang REN ; Wei-Ming ZHOU ; Yong-Heng WU ; Lei YAN ; Yi-Ping ZHOU
Author Information

1. Nanfang Hospital, First Military Medical University
Keywords: severe burn; infection; antibiotic
From: Journal of Southern Medical University 2000;20(6):549-550
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of early and short-term use of high-potency antibiotics following extensive severe burn injury. Methods Seventeen severely burned patients hospitalized in the same period (Nov, 1998 to Oct, 2000) were randomly divided into 2 groups. Patients in group 1 received early treatment with imipenum and amikacin for 5 d, and the same treatment in group 2 was discontinued on day 15 postburn. The survival rate, blood bacterial culture, body temperature and white blood cell and platelet counts were compared between the 2 groups. Results All the 17 patients survived and all blood bacterial cultures were negative. No significant difference in the body temperature or white blood cell and platelet counts between the 2 groups was observed (P>0.05). Conclusion Early use of high-potency antibiotics at a short treatment course after extensive severe burn is effective to prevent infection and reduce the cost.