Changes of plasma endothelin, atrial natriuretic peptide and hemodynamics during cardiopulmonary bypass in patients undergoing cardiac valve replacement surgery
10.3321/j.issn:1673-4254.2000.06.022
- VernacularTitle:心脏瓣膜置换术病人体外循环期间血浆内皮素、房钠利尿多肽和血流动力学变化
- Author:
Ji-Gui SONG
1
;
Guang-Jun XIAO
;
Wei-Xian ZHAO
Author Information
1. 1Nanfang Hospital First Military Medical University
- Keywords:
cardiac valve replacement surgery;
cardiopulmonary bypass;
endothelin;
atrial natriuretic peptide
- From:
Journal of Southern Medical University
2000;20(6):543-543
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of plasma endothelin (ET), atrial natriuretic peptide (ANP) and hemodynamics during cardiopulmonary bypass (CPB) in patients undergoing cardiac valve replacement surgery. Methods Sixteen patients underwent cardiac valve replacement surgery were investigated. Plasma endothelin, atrial natriuretic peptide were measured with radioimmunoassay. Results Before the anesthesia induction, plasma endothelin levels [(2.68±1.8)] pg/ml were not significantly different from that in the control group [(2.22±0.7) pg/ml] while atrial natriuretic peptide levels was significantly higher [(738±559) pg/ml vs (72.7±14.5 pg/ml, P<0.001)]. Plasma ET concentration was constant during CPB period. Plasma ANP levels gradually decreased after CPB started and returned to basal levels when CPB stopped. During and after CPB, SVRI was significantly lower compared with that preanesthesia. SVRI was positively correlated with Hct. Conclusions Plasma ET concentration does not significantly vary during CPB period. The decrease of plasma ANP levels can attribute to hemodilution, which also accounts for lowed SVRI.
