Effect of combined treatment with OK-432 and interleukine-2 and Bcl-2 expression in Lewis lung cancer in C57BL/6 mice

VernacularTitle:OK-432和IL-2联合用药对C57BL/6 小鼠Lewis肺癌的抑制作用及Bcl-2表达的影响
Author: Jie ZHOU ¹ ; Zhao-Xue SI ; Hong-Ling DONG ; Hai-Qing LIANG ; Jun-Wei CAI ; Ba-An SHAN ; Jing YANG
Author Information

1. Branch Campus of First Military Medical University
Keywords: OK-432; IL-2; bcl-2; lung cancer; anti-tumor effect; biotherapy
From: Journal of Southern Medical University 2000;20(6):517-518
CountryChina
Language:Chinese
Abstract: Objective To study the effect of OK-432 in combination with IL-2 on Lewis lung cancer (LLC) growth and bcl-2 expression in C57BL/6 mice. Methods Forty C57BL/6 mice bearing LLC were divided into 4 groups and injected with 0.9% NaCl solution, OK-432, IL-2 and OK-432/IL-2. The inhibition of tumor growth after the drug administration and the expression of bcl-2 in paraffin-embedded primary tumor tissues were observed with SABC. Results The growth of LLC in the group with combined treatment was significantly inhibited. ( with inhibition rate of 60%, P < 0.05). The expression of bcl-2 in this group was significantly lowered compared with control group (P < 0.05). Conclusions OK-432 and IL-2 has distinct synergetic anti-tumor effect, possibly by attacking the tumor cells directly or indirectly, and the improved interaction of cells due to inhibition of bcl-2 gene expression and induction of tumor cell apoptosis may also contribute to this effect.