The effects of triiodothyronine on energy metabolism and myocardial protection
10.3321/j.issn:1673-4254.2000.06.007
- VernacularTitle:三碘甲腺原氨酸对心肌细胞能量代谢的影响及其在心肌保护中的作用
- Author:
Qun-Qing CHEN
1
;
Yan-Chun CHEN
;
Yao-Chang SUN
;
Hui-Min HU
;
Zhi-Fei XU
Author Information
1. Zhujiang Hospital First Military Medical University
- Keywords:
triiodothyronine;
energy metabolism;
myocardial protection;
thyroid function;
ischemic reperfusion injury
- From:
Journal of Southern Medical University
2000;20(6):507-509
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of triiodothyronine (T3) on myocardial energy metabolism and its protection of the myocardial cells in rat ischemic reperfusion myocardial model with different thyroid functions. Methods The rats were categorized into group A (with normal thyroid function) and group B (with hypothyroidism), and each group were divided into blank control group, ischemic group, control reperfusion group and T3 reperfusion group. An isolated rat heart working model was established. The contents of ATP, ADP, AMP in the myocardial tissue in different groups were measured by high-performance liquid chromatographic method. Results The contents of ATP, ADP, AMP declined markedly in hypothyroidism group (P<0.01). Thirty minutes of ischemic arrest induced significant decrease of, ATP, ADP and AMP contents both groups A and B, which further declined when the hearts were subjected to 20 min of reperfusion. However ,the content of ATP increased markedly in T3 reperfusion groups compared with the control reperfusion groups in both group A:[(1.03±0.02) vs (0.62±0.02) mmol/g and group B:[(0.85±0.02) vs (0.40±0.01)] mmol/g (P<0.01). Conclusions Hypothyroidism or ischemic reperfusion injury may badly damage myocardial energy metabolism; T3 coold markedly increase the capacities of synthesizing and reserving ATP, improving myocardial protection.
