Establishment of a Gastrointestinal-Brain Inter-Organ Multimodal Characterization System Based on Traditional Chinese Medicine Theory and Its Application in Refractory Diseases
10.13288/j.11-2166/r.2025.06.004
- VernacularTitle:基于中医理论的胃肠-脑跨器官多模态表征体系的建立及其在难治性疾病中的应用
- Author:
Guanghui HAN
1
;
Yan GUO
2
;
Peijing RONG
3
;
Bin CONG
4
;
Shuangjiang LIU
5
;
Shaoyuan LI
6
;
Wei WEI
1
Author Information
1. Wangjing Hospital， China Academy of Chinese Medical Sciences，Beijing，100102
2. Xiyuan Hospital，China Academy of Chinese Medical Sciences
3. Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences
4. College of Forensic Medicine，School of Basic Medical，Hebei Medical University
5. State Key Laboratory of Microbial Resources，Institute of Microbiology，Chinese Academy of Sciences
6. Institute of Acupuncture and Moxibustion，China Academy of Chinese Medical Sciences
- Publication Type:Journal Article
- Keywords:
gut-brain axis;
multimodal characterization system;
refractory diseases
- From:
Journal of Traditional Chinese Medicine
2025;66(6):561-568
- CountryChina
- Language:Chinese
-
Abstract:
The concept of holism is the core idea of traditional Chinese medicine （TCM）. Various organs and tissues coordinate with each other to maintain the body's life activities， with a close and mutual influence between the spleen， stomach， and the central nervous system （brain）. The gut-brain axis plays an important bridging role between the digestive system and the central nervous system， achieving bidirectional information exchange between the brain and the gastrointestinal tract through complex neuroendocrine and immune mechanisms. The theory of cross-organ interaction involves the mutual influence， coordination， and integration between different organs and systems； multimodality， on the other hand， utilizes multiple sensory modalities， such as vision， hearing， and touch， to convey information. By combining TCM theory with the gut-brain axis theory， a cross-organ multimodal characterization system is established to explore its mechanism and application value in refractory diseases such as functional gastrointestinal disorders， precancerous gastrointestinal diseases， Alzheimer's disease， Parkinson's syndrome， type 2 diabetes， and depression.
