Research progress on antimicrobial peptides against methicillin-resistant Staphylococcus aureus
- VernacularTitle:抗耐甲氧西林金黄色葡萄球菌抗菌肽的研究进展
- Author:
Yuxuan WANG
1
;
Weichang GUO
2
;
Cheng CHEN
3
;
Yao LUO
1
;
Yaxiong XIAO
4
;
Jiangtao LI
5
Author Information
1. Department of Medical Affairs，the First People’s Hospital of Yibin，Sichuan Yibin 644000，China
2. Dept. of Vascular Surgery，the First People’s Hospital of Yibin，Sichuan Yibin 644000，China
3. Dept. of Pharmacy，the First People’s Hospital of Yibin，Sichuan Yibin 644000，China
4. Central Laboratory，the First People’s Hospital of Yibin，Sichuan Yibin 644000，China
5. Dept. of Rheumatology and Immunology，the First People’s Hospital of Yibin，Sichuan Yibin 644000，China
- Publication Type:Journal Article
- Keywords:
methicillin-resistant Staphylococcus aureus;
antimicrobial peptides;
mechanism of action;
drug resistance
- From:
China Pharmacy
2025;36(5):636-640
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus aureus is a Gram-positive bacterium with strong pathogenicity. With the widespread use of antibiotics， its multi-drug resistance has gradually increased. Among them， methicillin-resistant S. aureus （MRSA） is one of the main pathogens of hospital and community infections. Antimicrobial peptides are short-chain peptides with good antibacterial effects and low drug resistance， which have been widely studied in recent years. This study summarizes the mechanism of action of antimicrobial peptides and related study on antimicrobial peptides against MRSA from different sources. It is found that the mechanisms of action of antimicrobial peptides include targeting bacterial cell membranes， bacterial cells， and bacterial cell walls， etc. Besides isolating antimicrobial peptides with anti-MRSA activity from animals， plants， and microorganisms， antimicrobial peptides can also be obtained through synthetic methods. Among them， GHa-derived peptides from animal sources， Ib-AMP4 from plant sources， Ph-SA from microbial sources， the synthetic peptide LLKLLLKLL-NH2， and so on， due to their effective antibacterial activity， rapid bactericidal speed， and low toxicity， are promising candidates for anti-MRSA drugs.
