Progress in the application of poloxamer in new preparation technology
- VernacularTitle:泊洛沙姆在新型制剂技术中的应用进展
- Author:
Xue QI
1
,
2
;
Yi CHENG
2
;
Nan LIU
2
;
Zengming WANG
2
;
Hui ZHANG
2
;
Aiping ZHENG
2
;
Dongzhou KANG
1
Author Information
1. College of Pharmacy，Yanbian University，Jilin Yanji 133002，China
2. National Key Laboratory for Special Medicines Required for National Security，Academy of Military Medical Sciences，Beijing 100850，China
- Publication Type:Journal Article
- Keywords:
poloxamer;
preparation technology;
triblock copolymer structure;
carrier;
solid dispersion;
nanotechnology
- From:
China Pharmacy
2025;36(5):630-635
- CountryChina
- Language:Chinese
-
Abstract:
Poloxamer， as a non-ionic surfactant， exhibits a unique triblock [polyethylene oxide-poly （propylene oxide）-polyethylene oxide] structure， which endows it with broad application potential in various fields， including solid dispersion technology， nanotechnology， gel technology， biologics， gene engineering and 3D printing. As a carrier， it enhances the solubility and bioavailability of poorly soluble drugs. In the field of nanotechnology， it serves as a stabilizer etc.， enriching preparation methods. In gel technology， its self-assembly behavior and thermosensitive properties facilitate controlled drug release. In biologics， it improves targeting efficiency and reduces side effects. In gene engineering， it enhances delivery efficiency and expression levels. In 3D printing， it provides novel strategies for precise drug release control and the production of high-quality biological products. As a versatile material， poloxamer holds promising prospects in the pharmaceutical field.
