Research progress on the mechanism and clinical application of the effective ingredients from Sijunzi decoction in the treatment of gastric cancer
- VernacularTitle:四君子汤有效成分治疗胃癌的作用机制及临床应用研究进展
- Author:
Hongwei ZHANG
1
;
Wenfei DANG
1
;
Xin SUO
1
;
Ru ZHANG
1
;
Yan ZHANG
2
;
Ziming JIN
2
;
Xia DOU
2
Author Information
1. College of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Pharmaceutical Preparation Center，Affiliated Hospital of Gansu University of Chinese Medicine，Lanzhou 730020，China
- Publication Type:Journal Article
- Keywords:
Sijunzi decoction;
effective ingredients;
gastric cancer;
mechanism of action;
clinical efficacy
- From:
China Pharmacy
2025;36(5):624-629
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is a common malignant tumor of the digestive tract and can be classified as “fullness of the stomach”， “epigastric pain”， “noise” and other categories in the field of traditional Chinese medicine. Sijunzi decoction is composed of Panax ginseng， Poria cocos， Atractylodes macrocephala， and honey-fried Glycyrrhiza uralensis， and it has the effect of tonifying qi and strengthening the spleen. This article summarizes the active ingredients， mechanism of action， and clinical application research progress of Sijunzi decoction in treating gastric cancer. The results show that the main active ingredients of Sijunzi decoction include ginsenosides， atractylenolide， pachymic acid， glycyrrhizic acid， etc.； Sijunzi decoction and its effective ingredients can play an anti-gastric cancer role by inhibiting the proliferation of gastric cancer cell， inducing apoptosis of gastric cancer cell， enhancing gastric cancer cell chemotherapy sensitivity， and inhibiting invasion and metastasis of gastric cancer cell. In addition， Sijunzi decoction can enhance the efficacy of chemotherapy drugs， strengthen the immune function of the body and lower serum cancer marker levels during the clinical treatment of gastric cancer.
