Research progress on Pb-induced neurotoxicity through glial cells

VernacularTitle:铅通过胶质细胞诱发神经毒性的研究进展
Author: Na LUO ¹ ; Jin WANG ; Ziyang ZHANG ; Xinyuan ZHAO ; Rongrong HUANG ; Qiyun WU
Author Information

1. 南通大学公共卫生学院职业医学与环境毒理学系，南通　226000
Keywords: Lead; Microglia; Astrocytes; Oligodendrocytes; Cell activation; Neurodegenerative diseases
From: Chinese Journal of Preventive Medicine 2024;58(10):1610-1615
CountryChina
Language:Chinese
Abstract: Lead is one of the most important occupational hazards in China, and occupational exposure is the leading cause of lead poisoning. Lead can be absorbed by the body through air, food, drinking water and skin, and accumulate in multiple organs in the body, posing health risks to humans, especially to lead workers. Many previous studies have shown that lead can affect the function of glial cells such as microglia, astrocytes and oligodendrocytes, resulting in irreversible neurological damage. This article provides an overview of the neurotoxic mechanism induced by lead through glial cells, elucidates that lead can induce neurodegenerative diseases such as Alzheimer′s disease, Parkinson′s disease, and amyotrophic lateral sclerosis, and reviews the relationship between lead and glial cells, in order to provide reference for further research on the neurotoxic mechanism of lead on glial cells.