Current progress on trained immunity-based vaccines

VernacularTitle:基于训练免疫疫苗的研究进展
Author: Chuanying XIANG ¹ ; Ning WANG ; Yun SHI
Author Information

1. 四川大学华西医院华西生物制药研究院，成都610041
Keywords: Trained immunity; Vaccine; Innate immune memory
From: Chinese Journal of Preventive Medicine 2024;58(10):1598-1603
CountryChina
Language:Chinese
Abstract: Trained immunity-based vaccines (TIbV) is an emerging vaccine strategy in the field of vaccine research, referring to vaccines designed based on the principles of trained immunity (TI). TI involves the enhanced immune response of innate immune cells upon re-stimulation after being trained. TIbV, built on the concept of TI, aims to enhance resistance to various infectious pathogens by training the host′s innate immune system to acquire natural immune memory. This approach is designed to bolster immunity against a wide range of infectious agents, including those not covered by conventional vaccines. This article reviews the concepts, mechanisms, application areas, and future prospects of TIbV, intending to offer a new perspective for vaccine development and design.