Pathogenetic investigation of an outbreak of upper respiratory tract infection in a kindergarten in Baiyin City, Gansu Province
10.3760/cma.j.cn112150-20240330-00258
- VernacularTitle:甘肃省白银市1起幼儿园上呼吸道感染聚集性疫情的病原学调查
- Author:
Shu LIANG
1
;
Hui ZHANG
;
Zhibo XIE
;
Genxia GAO
;
Biao WANG
;
Miao WANG
;
Huan WEI
;
Xiaoshu ZHANG
Author Information
1. 甘肃省疾病预防控制中心病原检测所 甘肃省传染病病原学重点实验室，兰州 730000
- Keywords:
Upper respiratory tract infection;
Respiratory syncytial virus A;
Epidemic outbreak
- From:
Chinese Journal of Preventive Medicine
2024;58(10):1593-1597
- CountryChina
- Language:Chinese
-
Abstract:
This study focuses on the cases(mainly characterized by respiratory symptoms such as cough, runny nose, fever, sore throat, and nasal congestion)of an outbreak of upper respiratory tract infections in a kindergarten in Jingyuan County, Baiyin City, Gansu Province, in May 2023. The epidemiological data were collected, and pharyngeal swab specimens were also obtained from the patients. The specimens of the research participants were subjected to respiratory multi-pathogen testing, and the positive specimens were further analyzed by sequencing the second hypervariable region (HRV2) of the G gene of respiratory syncytial virus (RSV) and constructing a phylogenetic tree. A total of 90 patients were collected, with an incidence rate of 22.84% (90/394), and the highest incidence was observed in the junior class group at 29.55%. Among the 17 pharyngeal swab specimens collected, 16 specimens were identified with the A subtype of respiratory syncytial virus. Sequencing analysis confirmed that it was the A subtype ON1 genotype. Based on the aforementioned testing results, it can be concluded that the current epidemic was primarily caused by infection with the A subtype of respiratory syncytial virus. Following the implementation of intervention measures, the epidemic has been effectively controlled.
