Vaccine development based on RNA technology platforms

VernacularTitle:基于mRNA技术平台的疫苗研发进展
Author: Xiang GUO ¹ ; Jia LI ; Haomeng WANG ; Jing QIU ; Zhi LI ; Fang HUANG ; Juan LI ; Xiaodong SUN
Author Information

1. 上海市疾病预防控制中心免疫规划所，上海　200336
Keywords: Synthetic mRNA; mRNA modification; In vivo mRNA delivery; mRNA applications
From: Chinese Journal of Preventive Medicine 2024;58(8):1263-1277
CountryChina
Language:Chinese
Abstract: mRNA vaccine technology has made significant progress in recent years, especially with the large-scale application driven by the COVID-19 pandemic. Moderna and Pfizer/BioNTech vaccines have become central tools in the global fight against the virus, demonstrating the potential of the mRNA platform for rapid design, production, and strong immune responses. These vaccines showcase the unique advantages of rapid response and effective protection. At the same time, mRNA technology still faces challenges, such as stability and targeted delivery. Future research will focus on improving the stability and safety of mRNA vaccine and expanding its application to more infectious diseases and cancer treatments. This article reviews platforms of mRNA vaccine, vaccine design, development of delivery system, and the application of mRNA vaccines, in order to enhance the understanding of professionals and accelerate the layout of this technology in vaccine research and application in China.