Advances in the diagnosis and poor prognosis of diabetic hyperfiltration

VernacularTitle:糖尿病高滤过的诊断及其不良预后的研究进展
Author: Ruixuan MA ¹ ; Xuejing WANG ; Dingqiong PENG
Author Information

1. 北京大学民航临床医学院内分泌科，北京　100123
Keywords: Glomerular hyperfiltration; Diabetes mellitus; Sodium-glucose cotransporter 2 inhibitor
From: Chinese Journal of Preventive Medicine 2024;58(8):1256-1262
CountryChina
Language:Chinese
Abstract: Glomerular hyperfiltration(GHF), as an early manifestation of prediabetes and diabetic kidney disease, occurs mainly by the mechanism of glomerular-tubular feedback and hemodynamic alterations, and the risk of hyperfiltration can be elevated in younger patients, shorter duration of the disease, poor glycemic control, and high-protein, low-salt diet. Currently, there is no recognized standard for the definition of GHF, GHF lacks typical clinical manifestations, imaging diagnostic criteria are unclear, and GHF-related laboratory markers need to be further studied. Hyperfiltration, if not diagnosed and intervened in time, can accelerate the damage of nephron and the rate of nephropathy progression, and increase the risk of complications and death. Sodium-glucose cotransporter 2 inhibitor(SGLT2i), glucagon-like peptide-1 receptor agonist(GLP-1RA)and so on can effectively reverse the hyperfiltration state. Clinical attention should be paid to the diagnosis of diabetic hyperfiltration and the prevention of its poor prognosis.