From exposure to control: the application of allergen component-resolved diagnosis in the clinical management of cockroach allergies
10.3760/cma.j.cn112150-20240416-00312
- VernacularTitle:从暴露到控制：过敏原组分诊断技术在蟑螂过敏临床管理中的应用
- Author:
Jiale ZHANG
1
;
Xianhui ZHENG
;
Wenting LUO
;
Baoqing SUN
Author Information
1. 广州医科大学附属第一医院临床检验中心，呼吸疾病全国重点实验室，国家呼吸医学中心，国家呼吸系统疾病临床研究中心，广州呼吸健康研究院，广州510120
- Keywords:
Cockroach allergies;
Component-resolved diagnosis;
Blattella germanica;
Periplaneta americana
- From:
Chinese Journal of Preventive Medicine
2024;58(7):1103-1112
- CountryChina
- Language:Chinese
-
Abstract:
Cockroaches are one of the most common indoor allergens worldwide, and exposure to cockroach allergens (such as the insect body, debris, and secretions) can trigger severe allergic rhinitis and(or) asthma. Currently, the World Health Organization (WHO)/International Union of Immunological Societies (IUIS) has identified 32 allergenic components in cockroaches, but none of these allergens have shown a clear immunodominance. The sensitization rate to cockroach allergens shows significant variability across different regions and populations and exhibits cross-reactivity with various invertebrates, increasing the complexity of clinical diagnosis and treatment. This article delves into the "Molecular Allergology User′s Guide 2.0"(MAUG 2.0) published by the European Academy of Allergy and Clinical Immunology (EAACI) and the research progress on cockroach allergies both domestically and internationally. It elucidates the crucial role of allergen component diagnostic technology in enhancing the diagnosis and treatment of cockroach-induced allergic diseases, efficiently assisting clinicians in identifying common sensitizations and cross-reactivities, thereby offering patients more accurate diagnoses and personalized treatment plans.
