Research progress on the association between prenatal exposure to air pollutants and hypospadias in the offspring
10.3760/cma.j.cn112150-20240126-00095
- VernacularTitle:产前空气污染物暴露与子代尿道下裂关联的研究进展
- Author:
Lanjing XU
1
;
Jing GUO
;
Zhuchun ZHONG
;
Chenjun TANG
;
Xiaoming SHI
;
Guangdi CHEN
Author Information
1. 浙江大学医学院公共卫生学院，杭州 310058
- Keywords:
Air pollutants;
Hypospadias;
Fine particulate;
Prenatal;
Epidemiological study
- From:
Chinese Journal of Preventive Medicine
2024;58(7):1082-1086
- CountryChina
- Language:Chinese
-
Abstract:
Recent epidemiological studies have increasingly found that pregnant women who are exposed to air pollutants (for example airborne particulate matter, nitrogen oxides, ozone, and sulfur dioxide) increase the risk of various birth defects in their offspring, such as congenital heart disease, neural tube defects, cleft lip and palate, and hypospadias. Hypospadias not only impairs the sexual function of infants but also causes major social and psychological problems during their growth period, therefore, the prevention and treatment of hypospadias infant carry substantial public health importance. However, the association between prenatal exposure to air pollution and hypospadias remains controversial. The study reviews the epidemiological research progress and potential biological mechanisms of prenatal maternal exposure to air pollutants such as particulate matter, nitrogen oxides, ozone, sulfur dioxide, and the risk of hypospadias in offspring. The study also summarizes the limitations of previous research and looks forward to future research directions, to provide scientific evidence for creating a healthy living environment for pregnant women, and reducing the risk of hypospadias in offspring.
