Research progress on the role of imbalanced high and low molecular weight hyaluronic acid in respiratory system inflammation caused by atmospheric particulate matter

VernacularTitle:高低相对分子质量透明质酸失衡在大气颗粒物致呼吸系统炎症中作用的研究进展
Author: Xiaoyan YANG ¹ ; Lan WEI ; Yu′e ZHA ; Li LI ; Qin WANG
Author Information

1. 中国疾病预防控制中心环境与人群健康重点实验室　中国疾病预防控制中心环境与健康相关产品安全所，北京　100021
Keywords: Particulate matter; Low molecular weight hyaluronic acid; Hyaluronan synthase
From: Chinese Journal of Preventive Medicine 2024;58(5):608-614
CountryChina
Language:Chinese
Abstract: Atmospheric particulate matter has an association with respiratory system inflammation, and low molecular weight hyaluronic acid (LMW-HA) is a key biomarker of inflammatory cascade reaction. This review summarized the possible pathways and biomarkers of atmospheric particulate matter causing respiratory system inflammation through high molecular weight hyaluronic acid (HMW-HA)/LMW-HA imbalance, including the synthesis and decomposition of HA, the reduction of particulate matter and HMW-HA, the increase of LMW-HA, and the relationship between LMW-HA and respiratory system inflammation. Furthermore, inhibitors and therapeutic drugs targeting certain biomarkers were further listed. This review could shed light on the mechanism of respiratory system inflammation caused by atmospheric particulate matter and the weak points that need attention in subsequent research.