Association between long-term exposure to ambient ozone and sperm quality in Shandong Province
10.3760/cma.j.cn112150-20230818-00105
- VernacularTitle:山东省大气臭氧长期暴露与精子质量的关联研究
- Author:
Yinan QU
1
;
Wenkai HAN
;
Xiaohui SONG
;
Qi ZHAO
;
Wei MA
;
Li WANG
Author Information
1. 山东大学齐鲁医学院公共卫生学院流行病学系，济南 250012
- Keywords:
Ozone;
Spermatozoa;
Cohort studies;
Long-term exposure;
Sensitive population
- From:
Chinese Journal of Preventive Medicine
2024;58(5):592-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between long-term exposure to ambient ozone (O 3) and sperm quality. Methods:From January 1, 2014, to December 31, 2019, healthy sperm donors were recruited through the Human Sperm Bank of Shandong University Affiliated Reproductive Hospital. A total of 37 977 sperm donation data from 2 971 healthy volunteers were analyzed. The average annual O 3 concentration (0.01°× 0.01°) was matched according to household address. A multivariate mixed-effect model was used to analyze the exposure-response relationship between the average O 3 exposure concentration and sperm quality in the previous year, with each donor as a random intercept. All results were presented as % changes with 95% confidence intervals ( CIs) for all sperm parameters associated with 10 μg/m 3 increases in O 3. The effects of individual characteristics on the association between O 3 and sperm quality were evaluated by stratified analysis. Results:The average O 3 concentration in the year before semen collection was (107.09±7.50) μg/m 3. Each 10 μg/m 3 increase in O 3 was associated with declined sperm concentration (-3.12%, 95% CI:-4.55%, -1.67%), total sperm count (-5.21%, 95% CI:-7.28%, -3.09%), total sperm motility (-1.49%, 95% CI:-2.37%, -0.61%), progressive motility (-2.53%, 95% CI:-3.78%, -1.26%), total motile sperm count (-5.82%, 95% CI:-8.17%, -3.41%), and progressively motile sperm count (-6.22%, 95% CI:-8.73%, -3.64%). Men aged 30 and above, obese, and with lower education levels might be more susceptible to the influence of O 3 on sperm quality, but the difference was not statistically significant ( P>0.05). Conclusion:Long-term exposure to O 3 in Shandong Province is associated with a decrease in sperm quality.
