Analysis of molecular epidemic characteristics of H3N2 influenza viruses in Guangzhou City during the COVID-19 pandemic
10.3760/cma.j.cn112150-20230817-00101
- VernacularTitle:新冠疫情大流行期间广州市H3N2流感病毒分子流行特征分析
- Author:
Lan CAO
1
;
Tengfei ZHOU
;
Yiyun CHEN
;
Mengmeng MA
;
Dan XIA
;
Yanhui LIU
;
Kuibiao LI
;
Biao DI
;
Pengzhe QIN
;
Zhoubin ZHANG
Author Information
1. 广州市疾病预防控制中心病毒免疫部，广州 510440
- Keywords:
H3N2 influenza virus;
Molecular variation;
Genetic characteristics;
COVID-19;
Surveillance
- From:
Chinese Journal of Preventive Medicine
2024;58(3):351-357
- CountryChina
- Language:Chinese
-
Abstract:
To monitor and analyze the molecular variation of the H3N2 influenza virus in Guangzhou during the COVID-19 pandemic, respiratory samples of influenza-like cases from influenza monitoring sentinel hospitals were collected from influenza monitoring sentinel hospitals for virus isolation and whole genome sequencing. The results showed that during COVID-19, there was only one peak of H3N2 influenza in the second quarter of 2022 in Guangzhou (the positive rate was 52.23%), and the epidemic intensity and duration were both higher than those in 2019. The HA gene and NA gene of the epidemic strain in Guangzhou in 2022 belonged to the 3C.2a1b. 2a. 1a. 1 branch, which had a good antigenic site matching with the vaccine strain (A/Cambodia/e0826360/2020) from 2021 to 2022 and had no antigen drift. In 2022 strains, the variation of antigen determinant mainly occurred in the I48T of C region, while no variation occurred in the A, B, D, and E regions. The binding site of the HA protein receptor was consistent with the vaccine strain (A/Cambodia/e0826360/2020). Most of the strains in 2022 carried 13 glycosylation sites on the HA protein, but an outbreak of strains caused a loss of glycosylation sites at 24-NST. In conclusion, the strains that caused the epidemic of H3N2 influenza in Guangzhou in 2022 were not evolved or transmitted from the local strains in 2019 during the COVID-19 pandemic.
