Component-resolved diagnosis of tree pollen allergen: identify key allergens to develop treatment plans
10.3760/cma.j.cn112150-20231219-00463
- VernacularTitle:树花粉过敏原组分诊断策略：识别关键过敏原以制定治疗方案
- Author:
Wenting LUO
1
;
Xianhui ZHENG
;
Jiale ZHANG
;
Baoqing SUN
Author Information
1. 广州医科大学附属第一医院临床检验中心，呼吸疾病全国重点实验室，国家呼吸医学中心，国家呼吸系统疾病临床研究中心，广州呼吸健康研究院，广州 510120
- Keywords:
Tree pollen;
Allergen;
Allergy;
Component-resolved diagnosis
- From:
Chinese Journal of Preventive Medicine
2024;58(2):268-274
- CountryChina
- Language:Chinese
-
Abstract:
With the increasing global prevalence of tree pollen allergies, there has been a significant impact on the quality of life for populations. In North and Central China, birch pollen, cypress pollen, and plane tree pollen are the most common allergens for springtime pollen allergy sufferers. The distribution of plants and patterns of pollen transmission in different geographical areas result in varying pollen exposure outcomes, further complicating the challenges in diagnosis and individualized treatment. This article delves into the research progress and clinical application of tree pollen allergies based on the "Molecular Allergology User′s Guide 2.0 (MAUG 2.0) " published by the European Academy of Allergy and Clinical Immunology (EAACI). It discusses major allergen families and component proteins of tree pollen such as PR-10 proteins, profilins, polcalcins, as well as cross-reactive components that may cause pollen-food allergy syndrome. Allergen component diagnostics can distinguish true allergy sufferers from those with multiple allergen reactions, enabling more targeted selection of allergens for specific immunotherapy, thus enhancing treatment effectiveness. Bet v 1 and Cup a 1, for instance, are specific indicators for immunotherapy in birch and cypress allergy patients. Overall, this article provides cutting-edge information for professionals in the field of tree pollen allergies, offering in-depth exploration of tree pollen allergen component proteins, clinical manifestations, and treatment-related research, aiding in better understanding and addressing the challenges of tree pollen allergies.
