Association of urinary cadmium level with body mass index and body circumferences among older adults over 65 years old in 9 longevity areas of China
10.3760/cma.j.cn112150-20230912-00181
- VernacularTitle:中国9个长寿地区65岁及以上老年人尿镉水平与体重指数及身体围度的关联研究
- Author:
Zheng ZHANG
1
;
Bing WU
;
Yingli QU
;
Yang LI
;
Lanjing XU
;
Chunxian LYU
;
Chen CHEN
;
Jun WANG
;
Kai XUE
;
Yuan WEI
;
Jinhui ZHOU
;
Xulin ZHENG
;
Yidan QIU
;
Yufei LUO
;
Junxin LIU
;
Yuebin LYU
;
Xiaoming SHI
Author Information
1. 南京医科大学公共卫生学院全球健康中心，南京 211166
- Keywords:
Body mass index;
Aged;
Cross-sectional studies;
Urinary cadmium;
Body circumference
- From:
Chinese Journal of Preventive Medicine
2024;58(2):227-234
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of urinary cadmium level with body mass index (BMI) and body circumferences among the older adults over 65 years old in 9 longevity areas of China.Methods:Subjects were older adults over 65 years old from the Healthy Aging and Biomarkers Cohort Study (HABCS) between 2017 and 2018 conducted in 9 longevity areas in China. A total of 1 968 older adults were included in this study. Information including socio-demographic characteristics, lifestyles, diet intake, and health status was collected by using questionnaires and physical examinations. Urine samples were collected to detect urinary cadmium and creatinine levels. Body circumferences included waist circumference, hip circumference and calf circumference. Subjects were divided into three groups (low:<0.77 μg/g·creatinine, middle:0.77-1.69 μg/g·creatinine, high:≥1.69 μg/g·creatinine) by tertiles of creatinine-adjusted urinary cadmium concentration. Multiple linear regression models were used to analyze the association of creatinine-adjusted urinary cadmium level with BMI and body circumferences. The dose-response relationship of creatinine-adjusted urinary cadmium concentration with BMI and body circumferences was analyzed by using restrictive cubic splines fitting multiple linear regression model.Results:The mean age of subjects was (83.34±11.14) years old. The median (Q1, Q3) concentration of creatinine-adjusted urinary cadmium was 1.13 (0.63, 2.09) μg/g·creatinine, and the BMI was (22.70±3.82) kg/m 2. The mean values of waist circumference, hip circumference, and calf circumference were (85.42±10.68) cm, (92.67±8.90) cm, and (31.08±4.76) cm, respectively. After controlling confounding factors, the results of the multiple linear regression model showed that for each increment of 1 μg/g·creatinine in creatinine-adjusted urinary cadmium, the change of BMI, waist circumference, hip circumference, and calf circumference in the high-level group was -0.28 (-0.37, -0.19) kg/m 2, -0.74 (-0.96, -0.52) cm, -0.78 (-0.96, -0.61) cm, and -0.20 (-0.30, -0.11) cm, respectively. The restrictive cubic splines curve showed a negative nonlinear association of creatinine-adjusted urinary cadmium with BMI ( Pnonlinear<0.001) and negative linear associations of creatinine-adjusted urinary cadmium with waist circumference ( Plinear<0.001), hip circumference ( Plinear<0.001), and calf circumference ( Plinear<0.001). Conclusion:Urinary cadmium level is significantly associated with decreased BMI, waist circumference, hip circumference and calf circumference among older adults over 65 years old in 9 longevity areas of China.
