Heritability and genetic correlation of body mass index and coronary heart disease in Chinese adult twins
- VernacularTitle:中国双生子人群体重指数和冠心病遗传度和遗传相关性研究
- Author:
Yu′e XI
1
;
Wenjing GAO
;
Xuanming HONG
;
Jun LYU
;
Canqing YU
;
Shengfeng WANG
;
Tao HUANG
;
Dianjianyi SUN
;
Chunxiao LIAO
;
Yuanjie PANG
;
Zengchang PANG
;
Min YU
;
Hua WANG
;
Xianping WU
;
Zhong DONG
;
Fan WU
;
Guohong JIANG
;
Xiaojie WANG
;
Yu LIU
;
Jian DENG
;
Lin LU
;
Weihua CAO
;
Liming LI
Author Information
- Keywords: Coronary heart disease; Body mass index; Heritability; Genetic correlation; Twin study
- From: Chinese Journal of Preventive Medicine 2022;56(7):940-946
- CountryChina
- Language:Chinese
- Abstract: Objective:To examine the heritability of body mass index (BMI) and coronary heart disease (CHD), and to explore whether genetic factors can explain their correlation.Methods:Participants were from 11 provinces/municipalities reqistered in the Chinese National Twin Registry (CNTR) from 2010 to 2018. Participants data were collected from face-to-face questionnaire survey. Bivariate structure equation model was used to estimate the heritability and the genetic correlation of BMI and CHD.Results:A total of 20 340 pairs of same-sex twins aged ≥25 years were included in this study. After adjusting for age and gender, the heritability of BMI and CHD was 0.52 (95% CI: 0.49-0.55) and 0.76 (95% CI: 0.69-0.81), respectively. Further, a genetic correlation was identified between BMI and CHD ( rA=0.10, 95% CI:0.02-0.17). Conclusion:In Chinese adult twin population, BMI and CHD are affected by genetic factors, and their correlation can be attributed to the common genetic basis.
