Research progress of mast cell activation syndrome
10.3760/cma.j.cn112150-20210728-00722
- VernacularTitle:肥大细胞活化综合征的研究新进展
- Author:
Huali REN
1
;
Yongshi YANG
;
Jinlü SUN
Author Information
1. 国家电网公司北京电力医院 首都医科大学电力教学医院 变态反应科，北京 100073
- Keywords:
Mast cells;
Mastocytosis;
Immunoglobulin E;
Mediator
- From:
Chinese Journal of Preventive Medicine
2021;55(12):1513-1517
- CountryChina
- Language:Chinese
-
Abstract:
Mast cells are the main effector cells in allergic diseases. Allergic diseases are mostly a direct result of mast cell mediator release effects, while allergen activation is only one of many triggers for mast cell mediator secretion. Increased mast cell number, high mast cell reactivity, or both can lead to abnormal mast cell activation. Mast cell activated syndrome (MCAS) refers to a group or a"spectrum"of mediator-related, symptomatically similar diseases in which mast cells are stimulated by multiple factors. The symptoms and signs of mast cell disease overlap with allergic diseases, but the etiology is different, which requires clinical attention. This article summarizes the research progress on mast cell activation syndrome in recent years thus increase awareness of the differential diagnosis.
