Advances on physiology and pathology of subpopulations of macrophages in the lung tissue
10.3724/zdxbyxb-2024-0129
- VernacularTitle:肺组织中不同巨噬细胞的生理和病理研究进展
- Author:
Xiaohui ZHONG
1
;
Chengjie LYU
;
Dengming LAI
;
Qiang SHU
Author Information
1. 浙江大学医学院附属儿童医院心胸外科国家儿童健康与疾病临床医学研究中心国家儿童区域医疗中心,浙江 杭州 310052
- Keywords:
Macrophage;
Lung tissue;
Physiological;
Pathological;
Inflammation;
Immune;
Review
- From:
Journal of Zhejiang University. Medical sciences
2024;53(5):650-658
- CountryChina
- Language:Chinese
-
Abstract:
Macrophages are vital in maintaining tissue homeostasis in the lungs by modulating and regulating immune responses.Based on different origins and anatomical locations,macrophages in the lungs are categorized into alveolar macrophages,interstitial macrophages,perivascular macrophages,and inflammatory macrophages.Alveolar macrophages are located in the alveolar spaces and are primarily responsible for maintaining alveolar surfactant homeostasis,defending against pathogens and regulating immune responses.Interstitial macrophages can maintain homeostasis,regulate immunity and anti-inflammation in the lung tissue.Perivascular macrophages play a crucial role in inhibiting lung inflammation,improving pulmonary fibrosis,and regulating lung tumor progression due to antigen-presenting and immunomodulatory effects.Inflammatory macrophages,which are differentiated from monocytes during inflammation,regulate the inflammatory process.This article reviews the origins of various subpopulations of macro-phages in the lung tissue and their physiological and pathological functions as well as discusses the underlying mechanisms and potential therapeutic targets.
